miRNA Target Gene Identification: Sourcing miRNA Target Gene Relationships for the Analyses of TCGA Illumina MiSeq and RNA-Seq Hiseq Platform Data

Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data

Intracranial aneurysm (IA) remains one of the most devastating neurological conditions. However, the pathophysiology of IA formation and rupture still remains unclear. The purpose of the present study was to identify the crucial microRNA (miRNA/miR) and genes involved in IAs and elucidate the mechanisms underlying the development of IAs. In the present study, novel miRNA regulation activities i...

Expression Analysis of Let-7a miRNA and its Target Gene NRAS in Cytogenetically Normal Family with Myelodysplastic Syndrome

Myelodysplastic syndrome (MDS), is a group of heterogeneous disorders of hematopoietic stem cell colonies which is determined by incomplete hematopoiesis in one or more cell lines. The incidence increases with age and it has less been reported among patients under 50 years of age. The commonest form of MDS is sporadic, and familial occurrence of MDS is rare. Patients with familial MDS are young...

Identification of a novel miRNA-target gene regulatory network in osteosarcoma by integrating transcriptome analysis.

Osteosarcoma remains a leading cause of cancer death in children and young adolescents. Although the introduction of multiagent chemotherapy, survival rates have not improved in two decades. Therefore, it is urgently needed to know the details regarding molecular etiology to driving therapeutic inroads for this disease. In this study we performed an integrated analysis of miRNA and mRNA express...

Chapter 3 miRNA Target Prediction through Mining of miRNA Relationships Based on

ceRNAs: miRNA Target Mimic Mimics

In a recent issue of Cell, four papers described regulatory interactions among messenger RNAs (mRNAs) that share target sequences for the same microRNAs (miRNAs) (Cesana et al., 2011; Karreth et al., 2011; Sumazin et al., 2011; Tay et al., 2011). The authors state that these mRNAs, dubbed ‘‘competing endogenous RNAs (ceRNAs),’’ define a new layer of regulation of miRNA activity that has only re...